Publications
Selected publications
440 publications
Regulation of impulsive and aggressive behaviours by a novel lncRNA.
Nutrients or nursing? Understanding how breast milk feeding affects child cognition.
Brain-Derived Neurotrophic Factor in the Nucleus Accumbens Mediates Individual Differences in Behavioral Responses to a Natural, Social Reward.
Positive Maternal Mental Health, Parenting, and Child Development.
Is breastfeeding associated with later child eating behaviours?
Genetically predicted gene expression of prefrontal DRD4 gene and the differential susceptibility to childhood emotional eating in response to positive environment.
Correction: Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development.
Maternal antenatal anxiety and electrophysiological functioning amongst a sub-set of preschoolers participating in the GUSTO cohort.
Epigenetics, Development, and Psychopathology.
The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells.
Assessing for Mood and Anxiety Disorders in Parents of Clinically-Referred Children: Laying the Foundation for a Family-Based Approach to Mental Health in Singapore.
Prospective associations between parental feeding practices and children's oral processing behaviours.
Polygenic differential susceptibility to prenatal adversity.
Alternating optimization for G × E modelling with weighted genetic and environmental scores: Examples from the MAVAN study.
Fronto-parietal numerical networks in relation with early numeracy in young children.
Maternal Parenting Stress, Child Exuberance, and Preschoolers' Behavior Problems.
Neural Transcription Correlates of Multimodal Cortical Phenotypes during Development.
Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness.
Maternal Anxiety, Parenting Stress, and Preschoolers' Behavior Problems: The Role of Child Self-Regulation.
Association Between Repeated Episodes of Gastroenteritis and Mental Health Problems in Childhood and Adolescence.
A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment.
A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions.
Associations between inhibitory control, eating behaviours and adiposity in 6-year-old children.
Early environmental influences on the development of children's brain structure and function.
Maternal plasma vitamin B12 concentrations during pregnancy and infant cognitive outcomes at 2 years of age.
Gene expression profiling of single cells from archival tissue with laser-capture microdissection and Smart-3SEQ.
General psychopathology, internalising and externalising in children and functional outcomes in late adolescence.
Prefrontal Cortex Dopamine Transporter Gene Network Moderates the Effect of Perinatal Hypoxic-Ischemic Conditions on Cognitive Flexibility and Brain Gray Matter Density in Children.
Maternal symptoms of depression and sensitivity mediate the relation between maternal history of early adversity and her child temperament: The inheritance of circumstance.
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.
Once and Again : History of Rearing Experiences and Psychosocial Parenting Resources at Six Months in Primiparous Mothers.
Associations of maternal zinc and magnesium with offspring learning abilities and cognitive development at 4 years in GUSTO.
Sex-Dependent Associations among Maternal Depressive Symptoms, Child Reward Network, and Behaviors in Early Childhood.
Dissecting maternal care: Patterns of maternal parenting in a prospective cohort study.
Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development.
An initial investigation of neonatal neuroanatomy, caregiving, and levels of disorganized behavior.
Television viewing and child cognition in a longitudinal birth cohort in Singapore: the role of maternal factors.
Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome.
Perinatal maternal depressive symptoms alter amygdala functional connectivity in girls.
Relevance of Psychological Symptoms in Pregnancy to Intergenerational Effects of Preconception Trauma.
The dopamine D4 receptor gene, birth weight, maternal depression, maternal attention, and the prediction of disorganized attachment at 36 months of age: A prospective gene×environment analysis.
Generalization of Conditioned Auditory Fear is Regulated by Maternal Effects on Ventral Hippocampal Synaptic Plasticity.
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.
Fetal growth interacts with multilocus genetic score reflecting dopamine signaling capacity to predict spontaneous sugar intake in children.
The role of ethnicity and socioeconomic status in Southeast Asian mothers' parenting sensitivity.
FKBP5 Moderates the Association between Antenatal Maternal Depressive Symptoms and Neonatal Brain Morphology.
Epigenetic Regulation of the Kappa Opioid Receptor by Child Abuse.
Relation of plasma tryptophan concentrations during pregnancy to maternal sleep and mental well-being: The GUSTO cohort.
Treatment resistant depression: A multi-scale, systems biology approach.
The influence of perceived parenting styles on socio-emotional development from pre-puberty into puberty.
Systematic Overestimation of Reflection Impulsivity in the Information Sampling Task: Age Dependency in Children.
Community study found that cutaneous allergies in childhood were associated with conduct problems in girls.
Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus.
Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time.
Integration of "omics" Data and Phenotypic Data Within a Unified Extensible Multimodal Framework.
The early care environment and DNA methylome variation in childhood.
Does social capital moderate the association between children's emotional overeating and parental stress? A cross-sectional study of the stress-buffering hypothesis in a sample of mother-child dyads.
The role of breastfeeding in the association between maternal and infant cortisol attunement in the first postpartum year.
Moderating effect of PLIN4 genetic variant on impulsivity traits in 5-year-old-children born small for gestational age.
Birth weight and catch up growth are associated with childhood impulsivity in two independent cohorts.
Behavioral Heterogeneity in Relation with Brain Functional Networks in Young Children.
Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study-CORRIGENDUM.
PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores.
Uninterrupted Infant Sleep, Development, and Maternal Mood.
Perinatal Maternal Depressive Symptoms as an Issue for Population Health.
Eating in the absence of hunger: Stability over time and associations with eating behaviours and body composition in children.
Oral processing behaviours that promote children's energy intake are associated with parent-reported appetitive traits: Results from the GUSTO cohort.
Estrogen receptor α drives pro-resilient transcription in mouse models of depression.
SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates.
Comparison of DNA methylation measured by Illumina 450K and EPIC BeadChips in blood of newborns and 14-year-old children.
Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis.
Neonatal neural networks predict children behavioral profiles later in life.
An Attachment-Based Model of the Relationship Between Childhood Adversity and Somatization in Children and Adults.
IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice.
Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk.
Effects of bonding with parents and home culture on intercultural adaptations and the moderating role of genes.
A description of an 'obesogenic' eating style that promotes higher energy intake and is associated with greater adiposity in 4.5year-old children: Results from the GUSTO cohort.
The association between chronotype and sleep problems in preschool children.
Correction: IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice.
The joint contribution of maternal history of early adversity and adulthood depression to socioeconomic status and potential relevance for offspring development.
Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome.
Infant frontal EEG asymmetry in relation with postnatal maternal depression and parenting behavior.
Influences of prenatal and postnatal maternal depression on amygdala volume and microstructure in young children.
Sleep Quality and Nocturnal Sleep Duration in Pregnancy and Risk of Gestational Diabetes Mellitus.
Faster eating rates are associated with higher energy intakes during an ad libitum meal, higher BMI and greater adiposity among 4·5-year-old children: results from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort.
Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well-being: The growing up in Singapore toward healthy outcomes cohort.
Dynamic interaction between fetal adversity and a genetic score reflecting dopamine function on developmental outcomes at 36 months.
Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months.
Association of a History of Child Abuse With Impaired Myelination in the Anterior Cingulate Cortex: Convergent Epigenetic, Transcriptional, and Morphological Evidence.
BECon: a tool for interpreting DNA methylation findings from blood in the context of brain.
The Drosophila foraging gene human orthologue PRKG1 predicts individual differences in the effects of early adversity on maternal sensitivity.
Choice of surrogate tissue influences neonatal EWAS findings.
Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression.
Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study.
Broader Focus Required to Understand the Effects of the Perinatal Environment on Child Neurodevelopment: Response to Bell and Chimata.
Does the maternal vaginal microbiota play a role in seeding the microbiota of neonatal gut and nose?
Maternal care modulates the febrile response to lipopolysaccharide through differences in glucocorticoid receptor sensitivity in the rat.
Comparison of Methyl-capture Sequencing vs. Infinium 450K methylation array for methylome analysis in clinical samples.
Psychometric analysis of an eating behaviour questionnaire for an overweight and obese Chinese population in Singapore.
funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types.
Neuroanatomic Differences Associated With Stress Susceptibility and Resilience.
Effects of the Social Environment and Stress on Glucocorticoid Receptor Gene Methylation: A Systematic Review.
Genetic Differential Susceptibility to Socioeconomic Status and Childhood Obesogenic Behavior: Why Targeted Prevention May Be the Best Societal Investment.
Low birth weight associates with hippocampal gene expression.
Pre- and Post-Natal Maternal Depressive Symptoms in Relation with Infant Frontal Function, Connectivity, and Behaviors.
Associations between poor subjective prenatal sleep quality and postnatal depression and anxiety symptoms.
Mother nurture and the social definition of neurodevelopment.
Breastfeeding in the 21st century.
DRD4, Income, and Children's Food Choices: Plasticity Allele or Different Opportunities?-Reply.
Association of physical activity and sedentary behavior with depression and anxiety symptoms during pregnancy in a multiethnic cohort of Asian women.
ANXIETY AND DEPRESSION DURING PREGNANCY AND TEMPERAMENT IN EARLY INFANCY: FINDINGS FROM A MULTI-ETHNIC, ASIAN, PROSPECTIVE BIRTH COHORT STUDY.
The Influence of Gestational Diabetes on Neurodevelopment of Children in the First Two Years of Life: A Prospective Study.
Maternal prenatal felt security and infant health at birth interact to predict infant fussing and crying at 12 months postpartum.
Maternal childhood adversity and child temperament: an association moderated by child 5-HTTLPR genotype.
Infant feeding effects on early neurocognitive development in Asian children.
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes.
Maternal care differentially affects neuronal excitability and synaptic plasticity in the dorsal and ventral hippocampus.
COMT haplotypes modulate associations of antenatal maternal anxiety and neonatal cortical morphology.
Gender differences in the association between stop-signal reaction times, body mass indices and/or spontaneous food intake in pre-school children: an early model of compromised inhibitory control and obesity.
Spatial working memory and attention skills are predicted by maternal stress during pregnancy.
Breastfeeding and maternal sensitivity predict early infant temperament.
Establishment and consolidation of the sleep-wake cycle as a function of attachment pattern.
Back to basics: a bilingual advantage in infant visual habituation.
Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder.
Prenatal maternal depression alters amygdala functional connectivity in 6-month-old infants.
Early life trauma is associated with decreased peripheral levels of thyroid-hormone T3 in adolescents.
Antenatal maternal anxiety predicts variations in neural structures implicated in anxiety disorders in newborns.
Developmental synchrony of thalamocortical circuits in the neonatal brain.
Epigenetics/Programming in the HPA Axis.
Maternal sensitivity, infant limbic structure volume and functional connectivity: a preliminary study.
Prospective associations of appetitive traits at 3 and 12 months of age with body mass index and weight gain in the first 2 years of life.
The interplay of birth weight, dopamine receptor D4 gene (DRD4), and early maternal care in the prediction of disorganized attachment at 36 months of age.
Sleep duration and growth outcomes across the first two years of life in the GUSTO study.
Attachment disorganization among children in Neonatal Intensive Care Unit: Preliminary results.
Effects of Genotype and Sleep on Temperament.
Long-chain polyunsaturated fatty acid status during pregnancy and maternal mental health in pregnancy and the postpartum period: results from the GUSTO study.
The psychometric properties of the Quantitative-Checklist for Autism in Toddlers (Q-CHAT) as a measure of autistic traits in a community sample of Singaporean infants and toddlers.
HIF3A association with adiposity: the story begins before birth.
Concordant and discordant DNA methylation signatures of aging in human blood and brain.
Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour.
Poor infant inhibitory control predicts food fussiness in childhood - A possible protective role of n-3 PUFAs for vulnerable children.
Functional networks in parallel with cortical development associate with executive functions in children.
Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study.
Maternal anxiety and breastfeeding: findings from the MAVAN (Maternal Adversity, Vulnerability and Neurodevelopment) Study.
Association between the seven-repeat allele of the dopamine-4 receptor gene (DRD4) and spontaneous food intake in pre-school children.
Effect of maternal glycemia on neonatal adiposity in a multiethnic Asian birth cohort.
The influence of anxiety and depressive symptoms during pregnancy on birth size.
Transgenerational effects of maternal care interact with fetal growth and influence attention skills at 18 months of age.
The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes.
Low maternal sensitivity at 6 months of age predicts higher BMI in 48 month old girls but not boys.
Infinium monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis).
Better quality of mother-child interaction at 4 years of age decreases emotional overeating in IUGR girls.
The maternal adversity, vulnerability and neurodevelopment project: theory and methodology.
Alterations to DNA methylation and expression of CXCL14 are associated with suboptimal birth outcomes.
The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor.
Insights from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort study.
Gestational age and neonatal brain microstructure in term born infants: a birth cohort study.
Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring.
Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function.
Morphology and microstructure of subcortical structures at birth: a large-scale Asian neonatal neuroimaging study.
Early postnatal experience and DRD2 genotype affect dopamine receptor expression in the rat ventral striatum.
Maternal care associates with play dominance rank among adult female rats.
Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans.
Variations in maternal care associated with differences in female rat reproductive behavior in a group-mating environment.
Early maternal care predicts reliance on social learning about food in adult rats.
Genome-wide methylation changes in the brains of suicide completers.
Structural connectivity asymmetry in the neonatal brain.
Maternal anxiety and infants' hippocampal development: timing matters.
Dietary disinhibition modulates neural valuation of food in the fed and fasted states.
Decreased hippocampal mineralocorticoid:glucocorticoid receptor ratio is associated with low birth weight in female cynomolgus macaque neonates.
No moderating effect of 5-HTTLPR on associations between antenatal anxiety and infant behavior.
Interaction between oxytocin genotypes and early experience predicts quality of mothering and postpartum mood.
Genetic variation in oxytocin rs2740210 and early adversity associated with postpartum depression and breastfeeding duration.
Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth.
Maternal stress/distress, hormonal pathways and spontaneous preterm birth.
Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions.
Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD.
Executive functions of six-year-old boys with normal birth weight and gestational age.
Adult hippocampal glucocorticoid receptor expression and dentate synaptic plasticity correlate with maternal care received by individuals early in life.
Birth weight and gestation influence striatal morphology and motor response in normal six-year-old boys.
Preliminary evidence for an impulsivity-based thrifty eating phenotype.
Nature, nurture or nutrition? Impact of maternal nutrition on maternal care, offspring development and reproductive function.
Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse.
Maternal care influences hippocampal N-methyl-D-aspartate receptor function and dynamic regulation by corticosterone in adulthood.
Population differences in brain morphology and microstructure among Chinese, Malay, and Indian neonates.
Dopamine receptors D1 and D2 are related to observed maternal behavior.
Inattention and hyperactivity predict alterations in specific neural circuits among 6-year-old boys.
Genome-wide epigenetic regulation by early-life trauma.
Transcriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk.
Maternal licking regulates hippocampal glucocorticoid receptor transcription through a thyroid hormone-serotonin-NGFI-A signalling cascade.
Measuring the methylome in clinical samples: improved processing of the Infinium Human Methylation450 BeadChip Array.
Variations in postnatal maternal care and the epigenetic regulation of metabotropic glutamate receptor 1 expression and hippocampal function in the rat.
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus.
Blood pressure and retinal microvascular characteristics during pregnancy: Growing Up in Singapore Towards Healthy Outcomes (GUSTO) Study.
Environmental regulation of the neural epigenome.
Serotonin transporter allelic variation in mothers predicts maternal sensitivity, behavior and attitudes toward 6-month-old infants.
Variation in maternal care influences ventromedial hypothalamus activation in the rat.
Broad epigenetic signature of maternal care in the brain of adult rats.
Early adversity and serotonin transporter genotype interact with hippocampal glucocorticoid receptor mRNA expression, corticosterone, and behavior in adult male rats.
Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completers.
Affiliative behavior requires juvenile, but not adult neurogenesis.
Behavioral epigenetics.
Influence of birth weight on internalizing traits modulated by serotonergic genes.
Epigenetic regulation of the neural transcriptome: the meaning of the marks.
Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus.
Socioeconomic status and the brain: mechanistic insights from human and animal research.
Epigenetics and parental effects.
Non-stress-related factors associated with maternal corticotrophin-releasing hormone (CRH) concentration.
Enriching stress research.
Epigenetics and the biological definition of gene x environment interactions.
Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat.
Quality of parental emotional care and calculated risk for coronary heart disease.
Epigenetics and the environmental regulation of the genome and its function.
Epigenetics and the biological basis of gene x environment interactions.
Prenatal maternal stress from a natural disaster predicts dermatoglyphic asymmetry in humans.
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse.
Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus.
Stress pathways to spontaneous preterm birth: the role of stressors, psychological distress, and stress hormones.
Behavioral response to methylphenidate challenge: influence of early life parental care.
Environmental regulation of the neural epigenome.
The influence of birth size on intelligence in healthy children.
Neurobehavioral basis of the impaired nurturing in mice lacking the immediate early gene FosB.
Deactivation of the limbic system during acute psychosocial stress: evidence from positron emission tomography and functional magnetic resonance imaging studies.
The social environment and the epigenome.
Epigenetics, behaviour, and health.
It is time to take a stand for medical research and against terrorism targeting medical scientists.
Maternal influences on the sexual behavior and reproductive success of the female rat.
Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain.
Maternal programming of sexual behavior and hypothalamic-pituitary-gonadal function in the female rat.
Epigenetic programming of phenotypic variations in reproductive strategies in the rat through maternal care.
Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress.
Regional-specific global cytosine methylation and DNA methyltransferase expression in the adult rat hippocampus.
The effects of pH on DNA methylation state: In vitro and post-mortem brain studies.
Diet and the epigenetic (re)programming of phenotypic differences in behavior.
The influence of natural variations in maternal care on play fighting in the rat.
Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function.
Psychological stressors as a model of maternal adversity: diurnal modulation of corticosterone responses and changes in maternal behavior.
Effect of resource availability on biparental care, and offspring neural and behavioral development in the California mouse (Peromyscus californicus).
The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes.
Maternal care modulates the relationship between prenatal risk and hippocampal volume in women but not in men.
Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights.
Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health.
Maternal programming of defensive responses through sustained effects on gene expression.
Maternal separation leads to persistent reductions in pain sensitivity in female rats.
ERK-FosB signaling in dorsal MPOA neurons plays a major role in the initiation of parental behavior in mice.
Environmental programming of phenotypic diversity in female reproductive strategies.
Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty.
Glucocorticoid "programming" and PTSD risk.
Neurotensin receptor levels as a function of brain aging and cognitive performance in the Morris water maze task in the rat.
Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring.
Maternal programming of defensive responses through sustained effects on gene expression.
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood.
Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model.
Serotonin receptor binding and mRNA expression in the hippocampus of fearful amygdala-kindled rats.
Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring.
Influence of naturally occurring variations in maternal care on prepulse inhibition of acoustic startle and the medial prefrontal cortical dopamine response to stress in adult rats.
The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care.
Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life.
Maternal care as a model for experience-dependent chromatin plasticity?
The Douglas Hospital Longitudinal Study of Normal and Pathological Aging: summary of findings.
Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.
Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat.
Alpha1 adrenoreceptors mediate the stimulatory effects of oestrogen on stress-related hypothalamic-pituitary-adrenal activity in the female rat.
Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride.
Influence of early postnatal rearing conditions on mesocorticolimbic dopamine and behavioural responses to psychostimulants and stressors in adult rats.
Maternal behavior regulates benzodiazepine/GABAA receptor subunit expression in brain regions associated with fear in BALB/c and C57BL/6 mice.
Effect of neonatal handling and paternal care on offspring cognitive development in the monogamous California mouse (Peromyscus californicus).
Testosterone-dependent variations in plasma and intrapituitary corticosteroid binding globulin and stress hypothalamic-pituitary-adrenal activity in the male rat.
Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat.
Epigenetic programming by maternal behavior.
Maternal programming of individual differences in defensive responses in the rat.
Epigenetic programming of stress responses through variations in maternal care.
Preliminary evidence of altered sensitivity to benzodiazepines as a function of maternal care in the rat.
Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites.
Glucocorticoid programming.
Peripubertal environmental enrichment reverses the effects of maternal care on hippocampal development and glutamate receptor subunit expression.
Variations of maternal care differentially influence 'fear' reactivity and regional patterns of cFos immunoreactivity in response to the shock-probe burying test.
Variations in maternal care in the rat as a mediating influence for the effects of environment on development.
Partial reversal of the effect of maternal care on cognitive function through environmental enrichment.
Variations in maternal care alter GABA(A) receptor subunit expression in brain regions associated with fear.
Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area.
Long-term effects of BIBN-99, a selective muscarinic M2 receptor antagonist, on improving spatial memory performance in aged cognitively impaired rats.
Maternal care influences neuronal survival in the hippocampus of the rat.
Amygdala kindling increases fear responses and decreases glucocorticoid receptor mRNA expression in hippocampal regions.
From maternal care to gene expression: DNA methylation and the maternal programming of stress responses.
Maternal behavior regulates long-term hippocampal expression of BAX and apoptosis in the offspring.
Environmental enrichment reverses the effects of maternal separation on stress reactivity.
Acute modulation of aged human memory by pharmacological manipulation of glucocorticoids.
Amygdala kindling decreases insulin-like growth factor-I receptor binding sites in the rat hippocampus.
Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin (V1a) receptors: gender differences.
Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats.
Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse?
Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor.
Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity.
Nature, nurture, and the disunity of knowledge.
Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.
Can poverty get under your skin? basal cortisol levels and cognitive function in children from low and high socioeconomic status.
Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders.
Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites.
Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment.
Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors.
Long-term behavioral and neuroendocrine adaptations to adverse early experience.
Influence of neonatal rearing conditions on stress-induced adrenocorticotropin responses and norepinepherine release in the hypothalamic paraventricular nucleus.
The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat.
Neonatal handling permanently alters hypothalamic-pituitary- adrenal axis function, behaviour, and body weight in boars.
Enhanced nucleus accumbens dopamine and plasma corticosterone stress responses in adult rats with neonatal excitotoxic lesions to the medial prefrontal cortex.
5'-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events.
Postnatal handling increases the expression of cAMP-inducible transcription factors in the rat hippocampus: the effects of thyroid hormones and serotonin.
Maternal care, hippocampal synaptogenesis and cognitive development in rats.
Child's stress hormone levels correlate with mother's socioeconomic status and depressive state.
Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat.
Variations in maternal care in infancy regulate the development of stress reactivity.
Effect of amygdala kindling on emotional behavior and benzodiazepine receptor binding in rats.
Maternal care and the development of stress responses.
Corticosteroids, the Aging Brain and Cognition.
Maternal care, gene expression, and the development of individual differences in stress reactivity.
Nongenomic transmission across generations of maternal behavior and stress responses in the rat.
The role of corticotropin-releasing factor--norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress.
Increased cortisol levels and impaired cognition in human aging: implication for depression and dementia in later life.
Cortisol levels during human aging predict hippocampal atrophy and memory deficits.
Do early-life events permanently alter behavioral and hormonal responses to stressors?
Tissue-specific differences in rat glucocorticoid receptor gene transcriptional regulation.
Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat.
Reactivity to novelty in cognitively-impaired and cognitively-unimpaired aged rats and young rats.
Neurotrophin receptor and tyrosine hydroxylase gene expression in aged sympathetic neurons.
Dynamic variations in plasma corticosteroid-binding globulin and basal HPA activity following acute stress in adult rats.
Spatial memory in transgenic mice with impaired glucocorticoid receptor function.
Stress-induced declarative memory impairment in healthy elderly subjects: relationship to cortisol reactivity.
Central administration of the neurotensin receptor antagonist, SR48692, modulates diurnal and stress-related hypothalamic-pituitary-adrenal activity.
Antidepressants restore hypothalamic-pituitary-adrenal feedback function in aged, cognitively-impaired rats.
High-fat feeding alters both basal and stress-induced hypothalamic-pituitary-adrenal activity in the rat.
Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress.
Regulation of glucocorticosteroid receptor expression in rat hippocampal cell cultures by nerve growth factor.
Median eminence corticotrophin-releasing hormone content following prenatal stress and neonatal handling.
Longitudinal study of basal cortisol levels in healthy elderly subjects: evidence for subgroups.
Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress.
Changes in plasma adrenocorticotropin, corticosterone, corticosteroid-binding globulin, and hippocampal glucocorticoid receptor occupancy/translocation in rat pups in response to stress.
The inhibitory effect of testosterone on hypothalamic-pituitary-adrenal responses to stress is mediated by the medial preoptic area.
Plaque-forming cell responses and antibody titers following injection of sheep red blood cells in nonstressed, acute, and/or chronically stressed handled and nonhandled animals.
Hippocampal cell death.
Hippocampal cell death.
Ionotropic glutamate receptor subtypes in the aged memory-impaired and unimpaired Long-Evans rat.
The role of early environmental events in regulating neuroendocrine development. Moms, pups, stress, and glucocorticoid receptors.
Hippocampal neurodegeneration in aging.
Phasic hyperactivity of the HPA axis resulting from chronic central IL-2 administration.
The effects of early postnatal stimulation on Morris water-maze acquisition in adult mice: genetic and maternal factors.
Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired.
Neonatal endotoxin exposure alters the development of the hypothalamic-pituitary-adrenal axis: early illness and later responsivity to stress.
Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats.
Sex-specific effects of prenatal stress on hypothalamic-pituitary-adrenal responses to stress and brain glucocorticoid receptor density in adult rats.
Stimulation of CRH-mediated ACTH secretion by central administration of neurotensin: evidence for the participation of the paraventricular nucleus.
Hypothalamic-pituitary-adrenal function in chronic intermittently cold-stressed neonatally handled and non handled rats.
Increased production of inositol phosphates and diacylglycerol in aged cognitively impaired rats after stimulation of muscarinic, metabotropic-glutamate and endothelin receptors.
Effects of adrenalectomy and corticosterone replacement on glucocorticoid receptor levels in rat brain tissue: a comparison between western blotting and receptor binding assays.
Effects of chronic intermittent cold stress on pituitary adrenocortical and sympathetic adrenomedullary functioning.
Individual differences in hypothalamic-pituitary-adrenal activity in later life and hippocampal aging.
Estrogen-induced hypothalamic beta-endorphin neuron loss: a possible model of hypothalamic aging.
Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats.
Cholinergic markers in aged cognitively impaired Long-Evans rats.
Aldosterone modulates glucocorticoid receptor binding in hippocampal cell cultures via the mineralocorticoid receptor.
The interaction between prenatal stress and neonatal handling on nociceptive response latencies in male and female rats.
Basal cortisol levels and cognitive deficits in human aging.
Sex differences in hypothalamic-pituitary-adrenal responding to endotoxin challenge in the neonate: reversal by gonadectomy.
Regulation of the adrenomedullary catecholaminergic system after mild, acute stress.
Hypothalamic-pituitary-adrenal activation following endotoxin administration in the developing rat: a CRH-mediated effect.
Neonatal handling alters serotonin (5-HT) turnover and 5-HT2 receptor binding in selected brain regions: relationship to the handling effect on glucocorticoid receptor expression.
Studies of a neurochemical link between depression, anxiety, and stress from [3H]imipramine and [3H]paroxetine binding on human platelets.
Environmental regulation of the development of glucocorticoid receptor systems in the rat forebrain. The role of serotonin.
Hypothalamic-pituitary-adrenal activity during chronic central administration of interleukin-2.
Alterations in central catecholamines associated with immune responding in adult and aged mice.
Postnatal handling alters glucocorticoid, but not mineralocorticoid messenger RNA expression in the hippocampus of adult rats.
Glucocorticoid receptors in bovine adrenal medullary cells in culture: regulation by cyclic nucleotides.
Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease.
Increased plasma ACTH responses to stress in nonhandled compared with handled rats require basal levels of corticosterone and are associated with increased levels of ACTH secretagogues in the median eminence.
Central and feedback regulation of hypothalamic corticotropin-releasing factor secretion.
Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats.
Blockade of the hypothalamic-pituitary-adrenal response to stress by intraventricular injection of dexamethasone: a method for studying the stress-induced peripheral effects of glucocorticoids.
The effects of prostaglandin E2 injected into the paraventricular nucleus of the hypothalamus on brown adipose tissue thermogenesis in spontaneously hypertensive rats.
Relationship of social support to [3H]imipramine binding during and after examination stress.
Molecular basis for the development of individual differences in the hypothalamic-pituitary-adrenal stress response.
The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress.
Individual differences in the hypothalamic-pituitary-adrenal stress response and the hypothalamic CRF system.
Early life events and later development of ischaemic heart disease.
Entorhinal cortex lesions transiently alter glucocorticoid but not mineralocorticoid receptor gene expression in the rat hippocampus.
Changes in vasoactive intestinal Peptide binding site densities in the female rat central nervous system and pituitary during lactation.
Adrenal phenylethanolamine N-methyltransferase induction in relation to glucocorticoid receptor dynamics: evidence that acute exposure to high cortisol levels is sufficient to induce the enzyme.
Basal ACTH, corticosterone and corticosterone-binding globulin levels over the diurnal cycle, and age-related changes in hippocampal type I and type II corticosteroid receptor binding capacity in young and aged, handled and nonhandled rats.
Central administration of neurotensin stimulates hypothalamic-pituitary-adrenal activity. The paraventricular CRF neuron as a critical site of action.
Serotonergic regulation of type II corticosteroid receptor binding in hippocampal cell cultures: evidence for the importance of serotonin-induced changes in cAMP levels.
Peripheral benzodiazepine binding sites in Alzheimer's disease frontal and temporal cortex.
The effects of neonatal handling on the development of the adrenocortical response to stress: implications for neuropathology and cognitive deficits in later life.
Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats.
Cellular mechanisms underlying the development and expression of individual differences in the hypothalamic-pituitary-adrenal stress response.
Effects of corticosterone on response consolidation and retrieval in the forced swim test.
Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat.
Age-related changes in glucocorticoid receptor binding and mRNA levels in the rat brain and pituitary.
Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats.
Effects of aging on nicotinic and muscarinic autoreceptor function in the rat brain: relationship to presynaptic cholinergic markers and binding sites.
The role of serotonin in the development and environmental regulation of type II corticosteroid receptor binding in rat hippocampus.
Serotonin regulates type II corticosteroid receptor binding in hippocampal cell cultures.
Androgen binding sites in human temporal cortex.
The sexual differentiation of social play.
Glucocorticoid receptors in brain and pituitary of the lactating rat.
A comparison of the effects of diazepam versus several typical and atypical anti-depressant drugs in an animal model of anxiety.
Differential activation of the pituitary-adrenocortical axis after stress in the rat: use of two genetically selected lines (Roman low- and high-avoidance rats) as a model.
Role of the central benzodiazepine receptor system in behavioral habituation to novelty.
Temporally graded, age-related impairments in spatial memory in the rat.
Neonatal handling alters adrenocortical negative feedback sensitivity and hippocampal type II glucocorticoid receptor binding in the rat.
Effect of neonatal handling on age-related impairments associated with the hippocampus.
The effects of chronic antidepressant treatment in an animal model of anxiety.
The sexual differentiation of social play.
The effects of acute and life-long food restriction on basal and stress-induced serum corticosterone levels in young and aged rats.
Glucocorticoid binding sites in human temporal cortex.
Postmortem decay in glucocorticoid binding in human and primate brain.
Postnatal development and environmental regulation of hippocampal glucocorticoid and mineralocorticoid receptors.
Stress-induced occupancy and translocation of hippocampal glucocorticoid receptors.
Postnatal handling reduces novelty-induced fear and increases [3H]flunitrazepam binding in rat brain.
Thyroid hormones influence the development of hippocampal glucocorticoid receptors in the rat: a mechanism for the effects of postnatal handling on the development of the adrenocortical stress response.
The beta-endorphin response to stress during postnatal development in the rat.
Testosterone implants into the amygdala during the neonatal period masculinize the social play of juvenile female rats.
Increased pituitary sensitivity to glucocorticoid feedback during the stress nonresponsive period in the neonatal rat.
Molybdate stabilizes soluble [3H]dexamethasone binding sites in rat brain tissue in incubations at room temperature (22 degrees C).
Maturation of the adrenocortical stress response: neuroendocrine control mechanisms and the stress hyporesponsive period.
The development of the glucocorticoid receptor system in the rat limbic brain. III. Negative-feedback regulation.
The effects of postnatal handling on the development of the glucocorticoid receptor systems and stress recovery in the rat.
The development of the glucocorticoid receptor system in the rat limbic brain. I. Ontogeny and autoregulation.
The development of the glucocorticoid receptor system in the rat limbic brain. II. An autoradiographic study.
The effects of early postnatal handling on hippocampal glucocorticoid receptor concentrations: temporal parameters.
[3H]Dexamethasone binding in rat frontal cortex.
Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions.
Nuclear and cytosolic androgen receptor levels in the limbic brain of neonatal male and female rats.
[3H]dexamethasone binding in the limbic brain of the fetal rat.
In vitro measurement of cytosol and cell nuclear androgen receptors in male rat brain and pituitary.
Sexual differentiation of social play in rat pups is mediated by the neonatal androgen-receptor system.
The influence of glucocorticoids during the neonatal period on the development of play-fighting in Norway rat pups.
Neonatal-androgens influence the social play of prepubescent rats.
Sex-dependent effects of amygdaloid lesions on the social play of prepubertal rats.
Temporal boundary of the sensitive period for hormonal organization of social play in juvenile rats.
Differential effects of testosterone metabolites in the neonatal period on open-field behavior and lordosis in the rat.
No publications match. Try another search or clear the filters.